이름
이석우
(Lee, Seokwoo)
전공
약화학
연락처
연구실
생리활성물질합성연구실
최종학력
2010 - 2016 College of Pharmacy, Seoul National University (SNU) (Ph. D. in Pharmacy) 2006 - 2010 College of Pharmacy, Seoul National University (SNU) (B.S. in Pharmacy)
경력
2022 – 현재 College of Pharmacy, Chungnam National University (CNU) [Assistant Professor] 2021 – 2022 Research Institute of Pharmaceutical Sciences, Seoul National University (SNU) [Research Professor] 2021 – 2021 Research Institute of Pharmaceutical Sciences, Seoul National University (SNU) [Postdoctoral Associate] 2017 – 2020 Department of Chemistry, University of Pennsylvania (UPenn) [Postdoctoral Associate] 2016 - 2017 Research Institute of Pharmaceutical Sciences, Seoul National University (SNU) [Postdoctoral Associate]
관심연구분야
(1) Total synthesis of natural product (2) Medicinal chemistry (3) Computational chemistry
연구논문
(1) Soojun Park, Jiwoo Lee, Jae Hyun Kim, Yeji Jeong, Seokwoo Lee, Su Won Lee, Sanghee Kim, “Evolution of a Strategy for Concise Enantioselective Total Synthesis of the Salinosporamide Family of Natural Products” Angew. Chem. Int. Ed. ASAP (2) Hongjun Jeon, Sang Won Choi, Soojun Park, Seokwoo Lee, and Sanghee Kim, “Synthesis of Bridged Oxabicycles via Cascade Reactions involving O‑Acyloxocarbenium Ion Intermediates” Org. Lett. 2021, 23, 8312. (Co-corresponding author) (3) Seungbae Park, Seokwoo Lee, Jae Hyun Kim, Won Jun Choi, and Sanghee Kim, “Memory of Chirality in the Asymmetric Synthesis of Piperidines with Vicinal Stereocenters by Intramolecular Sn2’ Reaction” Chem. Asian. J. 2021, 16, 3097. (Co-first author) (4) Liudmila L. Mazaleuskaya, Seokwoo Lee, Hu Meng, Jeffrey D. Winkler, Garret A. FitzGerald, “Targeted delivery of mPGES-1 inhibitors to macrophages via the folate receptor-β for inflammatory pain” Bioorg. Med. Chem. Lett. 2021, 50, 128313. (Co-first author) (5) Tyler F. Higgins, Seokwoo Lee, and Jeffrey D. Winkle, “Synthesis of and Metal Complexation with a Chiral Cyclam” J. Org. Chem. 2021, 86, 5417. (Co-first author) (6) Jae Hyun Kim, Yundong Chung, Hongjun Jeon, Seokwoo Lee, and Sanghee Kim, “Stereoselective Asymmetric Synthesis of Pyrrolidines with Vicinal Stereocenters Using a Memory of Chirality-Assisted Intramolecular SN2′ Reaction” Org. Lett. 2020, 22, 3989. (7) Seokwoo Lee, Yun Mi Lee, Hyun-Ji Lee, Hongjun Jeon, Hyukjin Lee, Dongyun Shin, and Sanghee Kim, “Membrane Fusion through the Generation of Triazole Ceramide via Click Chemistry at the Membrane Surface" Asian J. Org. Chem. 2019, 8, 1713. (8) Hyunkyung Cho, Hongjun Jeon, Jae Eui Shin, Seokwoo Lee, Soojun Park, and Sanghee Kim, “Asymmetric Synthesis of Cα-Substituted Prolines via Curtin–Hammett Controlled Diastereoselective N-Alkylation” Chem. Eur. J. 2019, 25, 2447. (9) Hyunkyung Cho, Jae Eui Shin, Seokwoo Lee, Hongjun Jeon, Soojun Park, and Sanghee Kim, “Asymmetric Cα-Alkylation of Proline via Chirality Transfers of Conformationally Restricted Proline Derivative: Application to the Total Synthesis of (−)-Amathaspiramide F” Org. Lett. 2018, 20, 6121. (10) Sunhee Kang, Young Mi Kim, Heekyung Jeon, Sejin Park, Min Jung Seo, Saeyeon Lee, Dongsik Park, Jiyeon Nam, Seokwoo Lee, Kiyean Nam, Sanghee Kim, and Jaeseung Kim, "Synthesis and structure-activity relationships of novel fused ring analogues of Q203 as antitubercular agents” Eur. J. Med. Chem. 2017, 136, 420. (11) Heemin Park, Yongseok Kwon, Jae Eui Shin, Woo-Jung Kim, Soonho Hwang, Seokwoo Lee, and Sanghee Kim, "Orthoester in Cyclodehydration of Carbamate-Protected Amino Alcohols under Acidic Conditions" Synthesis 2017, 49, 2761. (12) Seokwoo Lee, Minsik Bae, Jinkyung In, Jae Hyun Kim, and Sanghee Kim, “Asymmetric Total Synthesis of Lepadiformine C Using Memory of Chirality in an Intramolecular Ester Enolate Michael Addition” Org. Lett. 2017, 19, 254. (13) Shuai Yu, Feng Li, Hongjun Jeon, Seokwoo Lee, Jongheon Shin, and Sanghee Kim, “Total Syntheses of Isowondonins Based on a Biosynthetic Pathway” Org. Lett. 2016, 18, 2986. (14) Jae Hyun Kim, Seokwoo Lee, and Sanghee Kim, "Biomimetic Total Synthesis of (−)-Penibruguieramine A Using Memory of Chirality and Dynamic Kinetic Resolution" Angew. Chem. Int. Ed. 2015, 54, 10875. (15) Hun Young Kim, Seokwoo Lee, Sanghee Kim, and Kyungsoo Oh, "Regiodivergent Halogenation of (E)-β-Chlorovinyl Ketones via Soft α-Vinyl Enolization Strategy" Org. Lett. 2015, 17, 450. (16) Jinkyung In, Seokwoo Lee, Yongseok Kwon, and Sanghee Kim, “Divergent Total Synthesis of the Tricyclic Marine Alkaloids Lepadiformine, Fasicularin, and Isomers of Polycitorols by Reagent-Controlled Diastereoselective Reductive Amination” Chem. Eur. J. 2014, 20, 17433. (17) Jihee Cho, Seokwoo Lee, Soonho Hwang, Sang Hoon Kim, Jong Seung Kim, and Sanghee Kim, “Calix[2]triazole[2]arenes; A Class of Hybrid Heterocalixarenes” Eur. J. Org. Chem. 2013, 4614. (18) Sumin Kim, Chaemin Lim, Sukjin Lee, Seokwoo Lee, Hyunkyung Cho, Joo-Youn Lee, Dong Sup Shim, Hee Dong Park, and Sanghee Kim, “Column Chromatography-Free Solution-Phase Synthesis of a Natural Piper Amide-Like Compound Library" ACS Comb. Sci. 2013, 15, 208. (19) Seokwoo Lee, Sukjin Lee, Hyen Joo Park, Sang Kook Lee, and Sanghee Kim, "Design and Synthesis of Pyrrolidine-Containing Sphingomimetics" Org. Biomol. Chem. 2011, 9, 4580. (20) Yun Mi Lee, Seokwoo Lee, Hongjun Jeon, Dong Jae Baek, Jae Hong Seo, Deukjoon Kim, and Sanghee Kim, “A Practical and Cost-effective Synthesis of D-erythro-Sphingosine from D-ribo-Phytosphingosine via a Cyclic Sulfate Intermediate” Synthesis 2011, 867. (21) Yun Mi Lee, Dong Jae Baek, Seokwoo Lee, Deukjoon Kim, and Sanghee Kim, “Regioselective Inversion of the Hydroxyl Group in D-ribo-Phytosphingosine via a Cyclic Sulfate and Bis-Sulfonate Intermediate” J. Org. Chem. 2011, 76, 408. (22) Seokwoo Lee, Soonho Hwang, Shuai Yu, Wonyoung Jang, Yun Mi Lee, and Sanghee Kim, “Synthesis and Evaluation of C-ring Aromatized Analogues of Phenanthridone Alkaloids” Arch. Pharm. Res. 2011, 34, 1065.